When the method is used in fitting logistic models in datasets giving rise to separation, theaffected estimate is typically approaching a boundary condition. As a result, the likelihood profileis often asymmetric under these conditions; Wald tests and confidence intervals are liable to beinaccurate. In these circumstances, Heinze and coworkers recommend using likelihood ratio testsand profile likelihood confidence intervals in lieu of Wald-based statistics. Calculation oflikelihood ratio test statistics with the method is done differently by Heinze and coworkers fromwhat is conventionally done: instead of omitting the variable of interest and refitting the reducedmodel, the coefficient of interest is constrained to zero and left in the model in order to allow itscontributing to the penalization. The test statistic is then computed as twice the difference inpenalized log likelihood values of the unconstrained and constrained models by lrtest in a mannerdirectly analogous to that of conventional likelihood ratio tests.