The differences between groups were assessed by analysis of variance. The
analysis of occlusion curves (percentage of animals without occlusion per hour)
was performed by using Kaplan-Meier method. Long Rank test was used to
assess differences among curves, with a Bonferroni correction to take into
account the problem of multiple comparisons. To evaluate FVII clearance, the
log-transformed curves of the factor VII levels decay were fitted against time.
Difference between slopes was evaluated with a separate-slopes model in
analysis of variance