Plasma t ½ is 6 to 8 h (not altered in patient with decreased hepatic or renal function). Metabolites excreted in urine and via the bile into the feces. Approximately 55% to 60% appears in urine as conjugates or unchanged labetalol within 24 h. Neither hemodialysis nor peritoneal dialysis removes a significant amount of labetalol from the general circulation.