Comments of reviewer 1 Manuscript Number: 3260 Manuscript Title: Retroperitoneal Castleman's disease misdiagnosed as hepatocellular carcinoma in the left caudate lobe 1. A mistake in the case report section. HBV core antigen cannot detect in the peripheral blood but the liver tissue. Is it positive to HBeAg or HBcAb in the serum? 2. The tumor is located at the retroperitonieum but closely contact the left lobe liver base without intrahepatic Doppler signal inside the tumor. Transhepatic liver biopsy may be needed to have a pre-operation evaluation for r/o nodular hyperplasia, lymphoma, adenoma, or other benign process because of the asymptomatic condition. 3. Under the HCC management guideline, young age HBsAg carrier without liver cirrhosis or high AFP, hypovascular mass is not satisfied to do a major operation before a tissue diagnosis have been make. 4. A young age female with unknown married status, a big surgical scar on the abdomen may not feel good in her life except a strongly evidence of malignance have been make.