The majority of matrix effects occur in the solvent front ofa chromatographic run [30]. Thus intuitively if the analytescan be retained chromatographically to some degree thenmatrix effects can be minimized. Data obtained frompostcolumn infusion experiments can provide data on wherematrix effects are occurring. Thus using these data to movethe analytes away from these affected areas provides for amore stable method. These changes may limit the aim ofhigh-throughput analysis. An alternative approach is to applya rapid gradient or bballistic gradientQ to separate the analytesfrom the solvent front while maintaining high throughput [6].