This is the first data set to show region-specific increases in human CBF following a flavanone dose. The frontal gyrus has been identified within a network of brain areas that are active during conscious resting state(23), which may explain the observed region-specific increased perfusion. The inferior frontal gyrus has typically been implicated in tasks that require inhibition, planning, decision making and other aspects of executive function(24), such as the DSST, for which improvements were observed in this study following the flavanone-rich juice. However, the mechanisms underpinning the right hemispheric lateralisation are unclear.