There are few data available for multi-modal rehabilitation programmes incorporating exercise and nutritional interventions for patients with incurable cancer. However, of those outcomes important to patients, many showed improvements following the interventions described.Factorsassociatedwith programmecompletionarehigherbaselinenutritionalorfunctional status and lower levels of inflammation. Of the studies analysed, methodological quality was frequently limited by study design and statistical power. Heterogeneity of studydesign(includinginterventionsandoutcomemeasures)meant meta-analysis was not appropriate. In patients with incurable cancer, the highest quality of evidencepertainstoimprovementsindepressionandphysical endurance following multi-modal rehabilitation programmes including exercise and nutritional support. Depression is one of the commonest mental health problems in patients with advanced cancer [29]. Six studies showed improvements in depression scores, using outcomes including the Hospital Anxiety and Depression Scale (HADs). This scale, however, does not differentiate clinical depression from sub-threshold symptomatology,whichisalimitationtoitsuseinthispatient population [27]. Ahighlevelofevidenceexistsforexerciseinrehabilitation trials [2, 30], and this review suggests that the combination of exerciseandnutritionalsupportalsoimprovesphysicalenduranceinpatientswithincurable cancer. Evidencefor changein overallfunctionremainsverylowduetoseriouslimitationsin the evidence (Table 2). Plausibly however, improvements in physicalendurance mayimpactonoverall functionviareductions in dependency.