请在这里输入要翻译的内容Demonstrating the importance of the gut microbiota in human health and well-being represents a major trans-
formational task in both medical and nutritional research. Owing to the high-throughput -omics methodologies, the
complexity, evolution with age, and individual nature of the gut microflora have been more thoroughly investi-
gated. The balance between this complex community of gut bacteria, food nutrients, and intestinal genomic and
physiological milieu is increasingly recognized as a major contributor to human health and disease. This article
discusses the ‘‘gutome,’’ that is, nutritional systems biology of gut microbiome and host–microbiome interactions.
We examine the novel ways in which the study of the human gutome, and nutrigenomics more generally, can have
translational and transformational impacts in 21st century practice of biomedicine. We describe the clinical context
in which experimental methodologies, as well as data-driven and process-driven approaches are being utilized in
nutrigenomics and microbiome research. We underscore the pivotal importance of the gutome as a common
platform for sharing data in the emerging field of the integrated metagenomics of gut pathophysiology. This vision
needs to be articulated in a manner that recognizes both the omics biotechnology nuances and the ways in which
nutrigenomics science can effectively inform population health and public policy, and vice versa.