In this paper, low-cycle fatigue behavior of open-cell aluminum foam under compression-compression loadingwas studied using a microstructural finite element model and experiments. Using microscopic images and digital camera, some of the physical properties were extracted, including the beam's thickness, forming the cell wall, cell size, relative density and microstructure layout.A static test was performed under compressive loading on the open-cell aluminum foam and the yield stress was obtained from the stress-strain curve. In order to obtain low-cycle fatigue life, five loading levels were selected as fractions of the obtained yield stress. Low-cycle fatigue behavior of the aluminum foam was obtained using a microstructure finite element model. The strain-cycle curve from fatigue tests and a microstructure model foropen-cell aluminum foam were obtained.