Hydroxyethyl starch, (HES) is a synthetic polymer prepared by reacting naturally occurring amylopectin with ethylene oxide resulting in hydroxyethyl groups being added to oxygen at different carbon positions at glucopyranose unit C2, C3, or C6 to be in the final form of α-1,4-linked d-glucopyranose residues (Kalhorn et al., 1984). HES has valuable medical applications e.g. as blood plasma volume expander polymers (Deitrich, 2001). Leukapheresis agent, as cryo-preservative (Kalhorn et al., 1984), as polymer drug delivery, (Kamoun and Menzel, 2012) and as blood isotonic electrolyte solutions, which further evidenced its non toxicity, biodegradability, and biocompatibility with the human body.(Dorothee et al., 1998) Thus, HES has been chosen to incorporate with PVA membranes due to its unique biomedical characteristics mentioned earlier, additionally its appealing intrinsic properties e.g. high hydrophilicity, abundance natural sources, and low cost polymers compared to other polysaccharides e.g. sodium alginate and dextran, which have been previously blended with PVA membranes.