401. Int J Radiat Oncol Biol Phys.

401. Int J Radiat Oncol Biol Phys. 1993 Apr 30;26(1):117-23.

Bronchoalveolar lavage fluid findings following radiotherapy for non-small cell
lung cancer.

Maasilta P(1), Hallman M, Taskinen E, Kivisaari L, Mattson K.

Author information:
(1)Department of Pulmonary Medicine, Helsinki University Central Hospital,
Finland.

PURPOSE: To evaluate the diagnostic potential of bronchoalveolar lavage fluid
analysis in radiation-induced lung injury.
METHODS AND MATERIALS: Thirty patients with inoperable non-small cell lung cancer
received either high-dose hyperfractionated radiotherapy or radiotherapy and
interferon, a potential radiosensitizer, or radiotherapy and N-acetylcysteine, a
potential radioprotector. Bronchoalveolar lavages were performed before and
immediately after radiotherapy, and thereafter 6-8 weeks and 3 months after
radiotherapy. Total and differential cell counts were measured from the
bronchoalveolar lavage fluid samples. Urea measured in serum and in
bronchoalveolar lavage fluid was used to calculate epithelial lining fluid. The
concentrations of protein and phosphatidylcholine, the major surfactant
phospholipid, in epithelial lining fluid were measured. The extent of
radiation-induced lung injury was assessed from computed tomographies performed
before radiotherapy, and 6-8 weeks and 3 months after radiotherapy.
RESULTS: More patients in the interferon-arm developed radiation pneumonitis than
did patients in the other groups, but no significant differences in alveolar
fluid indices were noted between the groups. When all the patients were studied
together, radiation was shown to have induced a significant relative increase of
lymphocytes in bronchoalveolar lavage fluid 6-8 weeks and 3 months after the end
of radiotherapy. The concentration of phosphatidylcholine in epithelial lining
fluid decreased significantly 6-8 weeks and 3 months after treatment. The
increase in protein concentration in epithelial lining fluid reached a
statistically significant level 6-8 weeks after radiotherapy.
CONCLUSION: Analysis of bronchoalveolar lavage fluid predicts the degree of
radiation pneumonitis; however, radiology remains to be "the gold standard."

PMID: 8387063 [PubMed - indexed for MEDLINE]

結果 (中文) 1:

401.Int J 辐射 Oncol 生物学与物理 1993 Apr 30; 1:117-23。支气管肺泡灌洗流体发现放射治疗非小细胞后肺癌患者。Maasilta p （1)，黑米，Taskinen E，Kivisaari L，麦特 k。作者信息︰(1)赫尔辛基大学中心医院，肺医学系芬兰。目的︰ 评价支气管肺泡灌洗液的诊断潜力分析在辐射引起的肺损伤。方法和材料︰ 三十患者不能动手术的非小细胞肺癌收到或高剂量超分割放射治疗或放射治疗和干扰素、 潜在的增敏剂，或放疗和 N-乙酰半胱氨酸，潜在的防护。灌进行之前和放射治疗后立即, 此后 6-8 周和 3 个月后放射治疗。总和差别细胞计数测量支气管肺泡灌洗的流体样品。尿素测定血清及支气管肺泡灌洗液用于计算上皮衬里流体。的蛋白质和磷脂酰胆碱，主要的表面活性剂的浓度测定了磷脂上, 皮衬里液中。程度放射性肺损伤的评估从执行的计算 tomographies放疗前, 6-8 周和放疗后 3 个月。结果︰ 更多的患者，干扰素挽开发比放射性肺炎其他组，患者却在肺泡中的无显著差异组间注意到流体指数。当所有的病人进行了研究在一起，辐射被证明有诱导相对显著增加支气管肺泡灌洗液中的淋巴细胞 6-8 周和 3 个月后结束放射治疗。浓度的磷脂酰胆碱在上皮衬里液显著降低 6-8 周内和治疗后 3 个月。的达成的上皮衬里液中的蛋白质浓度的增加放疗后 6-8 周水平有统计学意义。结论︰ 支气管肺泡灌洗液分析预测的程度放射性肺炎;然而，放射学还有待"黄金标准"。PMID: 8387063 [PubMed-索引为 MEDLINE]

結果 (中文) 2:

401.诠释J放射肿瘤学生物学物理学。1993年4月30日; 26（1）：117-23。

以下放疗非小细胞支气管肺泡灌洗液发现
肺癌。

Maasilta P（1），霍尔曼男，Taskinen E，Kivisaari L，马特森K.

作者信息：
（1）肺药，赫尔辛基大学中心医院系
芬兰。

目的：评价支气管肺泡灌洗液的诊断潜力
分析放射性肺损伤。
材料与方法：30例不能手术的非小细胞肺癌患者
分别接受高剂量放疗超分割放疗或与
干扰素，一个潜在的放射增敏剂，或放疗和N-乙酰半胱氨酸，一个
潜在的辐射防护剂。支气管灌洗之前和进行
放疗后立即，之后6-8周和3个月后
放疗。总的和不同的细胞计数从测量
支气管肺泡灌洗液样本。在血清和测定尿素
支气管肺泡灌洗液被用来计算上皮细胞衬液。的
蛋白质和磷脂酰胆碱的浓度，主要的表面活性剂
的磷脂，在上皮细胞衬液进行测定。的程度
辐射引起的肺损伤是由计算机进行评估tomographies
放疗前，和6-8周，放疗后3个月。
结果：更多的病人在干扰素臂研制放射性肺炎比
其他组没有病人，但在肺泡无显著差异
流体指数是组间注意到。当所有的患者进行了研究
一起，被示出辐射到已诱导的显著相对增加
淋巴细胞在支气管肺泡灌洗液6-8周，3个月结束后
放疗。在上皮衬里磷脂的浓度
的流体处理6-8周和3个月后显著降低。该
在上皮细胞衬液蛋白浓度的增加达到了
放射治疗后6-8周统计显著水平。
结论：支气管肺泡灌洗液分析预测度
放射性肺炎; 然而，放射科仍然是“黄金标准”。

结论：8387063 [考研-编入索引的MEDLINE]