The MFIS has an excellent reliability among people with MS, and it assesses the high levels of fatigue better than other fatigue questionnaires. Total scores on the subscales are reported, along with an aggregate score which is the sum of the three subscales. Scores range from 0 to 84 with higher scores indicating greater impact from fatigue. Depression is measured using the Hospital Anxiety and Depression Scale (HADS). This is a 14-item questionnaire that includes seven items for anxiety and seven for depression, with items scored on a scale of 0 to 3. The HADS is a valid measure of both anxiety and depression. Anxiety and depression subscale scores are the summed scores of the items related to anxiety and depression, and are reported separately.