There is still a long way to go to transform the Greek health system into an efficient, equitable and sustain-able system. This transformation, however, needs to be directed by transparent and evidence-based decisions. Cre-ating the appropriate information-related infrastructure, such as HTA, Socio-Economic Evaluation, Quality Measure-ment and Patient Satisfaction as well as Empowerment Guidelines will assist consumers, clinicians and policy-makers in a wide range of decisions. Perhaps, the tragedy of the economic crisis will prove to have at least one “silver lining” allowing for a better health system in the future.