Whereas wt and rd1 mice improved their performance over the next 2 days the
learning curve for ak mice was nearly flat (Fig.1, Top Panel). Analysis of
the learning curves demonstrated a main effect of day F(2,62) =53.91,
pb0.0001 and genotype F(2,62) =10.35, pb0.0004 and an interaction
between day and genotype F(4,62) =8.69, pb0.0001. To further assess
the magnitude of rotarod learning across days we compared the
difference between rotarod latency on day 1 and rotarod latency on
day 3 between all three groups. ak mice demonstrated a smaller
improvement (Fig. 1, Bottom Panel) over the 3 days compared to wt
(pb0.05) and rd1 mice (pb0.01), consistent with impaired motor
learning.