Elevated levels of 33,7a-diol 4 in liver from patients with cerebrotendinous xanthomatosis, of (24S)-3B, 24-diol 9 in myelinating mammalian central nervous tissue, and of (25R)-3B, 26-diol 11 and fatty acyl esters of 3B,24-diol 9 and 33,26-diol 11 in human atheromatous aortal tissue suggest processes of accumulation occur, significance unknown.