Electrospinning Thermoplastic Polyurethane-Contained Collagen Nanofibers for Tissue-Engineering Applications。
Electrospinning is a new method used in tissue engineering. It can spin fibers in nanoscale by electrostatic force. A series of thermoplastic polyurethane (TPU)/collagen blend nanofibrous membranes was prepared with different weight ratios and concentrations via electrospinning. The two biopolymers used 1,1,1,3,3,3,-hexafluoro-2-propanol (HFP) as solvent. The electrospun TPU-contained collagen nanofibers were characterized using scanning electron microscopy (SEM), XPS spectroscopy, atomic force microscopy, apparent density and porosity measurement, contact-angle measurement, mechanical tensile testing and viability of pig iliac endothelial cells (PIECs) on blended nanofiber mats. Our data indicate that fiber diameter was influenced by both polymer concentration and blend wei