The Model F-value of 250.24 implies the model is significant. There is only a 0.01% chance that a "Model F-Value" this large could occur due to noise.
Values of "Prob > F" less than 0.0500 indicate model terms are significant.
In this case B, C, A++2+-, B++2+-, C++2+- are significant model terms.
Values greater than 0.1000 indicate the model terms are not significant.
If there are many insignificant model terms (not counting those required to support hierarchy), model reduction may improve your model.
The "Lack of Fit F-value" of 1.20 implies the Lack of Fit is not significant relative to the pure error. There is a 41.63% chance that a "Lack of Fit F-value" this large could occur due to noise. Non-significant lack of fit is good -- we want the model to fit.