目的: 通过病例对照研究分析胃癌患者与健康人群血浆某些化学元素的差异及

目的: 通过病例对照研究分析胃癌患者与健康人群血浆某些化学元素的差异及其与胃癌的关系。方法: 采用成组病例对照研究方法，收集在仙游县本地居住10年以上，并经病理确诊的新发胃癌病例共299例，胃癌死亡率相近居住地的健康对照295例。通过问卷调查及血样采集等方式获取病例及对照组的一般情况、生活习惯等信息，运用微波消解法处理血样，电感耦合等离子体质谱法检测血浆化学元素。运用非参数检验比较两组人群血浆中化学元素含量的差异。结果：血浆化学元素在病例组和对照组中存在差异，病例组中Cu、Mg、Cu/Zn高于对照组（P

結果 (英文) 1:

Objective: through the analysis of case-control study of gastric cancer patients with healthy people of difference of plasma levels of some chemical and its relationship with gastric cancer. Methods: case-control study group collected in Xianyou County local living more than 10 years, and pathologically confirmed cases of new-onset gastric 299 patients, healthy control of 295 cases of gastric cancer mortality rates close to their place of residence. Through questionnaires and blood samples and other ways to get case and control groups in General, lifestyle habits and other information, using microwave digestion method for treating blood, plasma chemical elements by inductively coupled plasma-mass spectrometry. Using non-parametric tests comparing plasma content of chemical elements in different groups. Results: plasma chemical elements in cases group and control group in the exists differences, cases group in the Cu, and Mg, and Cu/Zn above control group (P<0.01), cases group in the Mo, and Ca below control group (P<0.01); through more factors analysis found plasma Cu (OR=2.64), and Mg (OR=2.20), and Cu/Zn (OR=3.89) increased gastric cancer onset of risk, Mo (OR=0.52), and Ca (OR=0.16) Reduce the risk of stomach cancer. Conclusion: plasma levels of some chemical elements in gastric cancer patients than in normal population has changed significantly.

結果 (英文) 2:

Objective: To analyze the differences in gastric cancer patients and healthy people plasma of certain chemical elements and its relationship with gastric cancer through case-control. Methods: A case-control study group collected in Xianyou local live 10 years or more, and new hair gastric cancer confirmed by pathology of a total 299 cases of gastric cancer mortality similar to live healthy controls 295 cases. Get cases and the control group through questionnaires and collected blood samples, etc. In general, living habits and other information, the use of microwave digestion process blood samples by inductively coupled plasma mass spectrometry plasma chemical elements. Using non-parametric tests compare differences between chemical element contents of the two groups in plasma. Results: The plasma chemical elements there are differences between cases and controls in the case group Cu, Mg, Cu / Zn was higher (P <0.01), the case group Mo, Ca lower than the control group (P <0.01) ; multivariate analysis showed that plasma Cu (OR = 2.64), Mg (OR = 2.20), Cu / Zn (OR = 3.89) increase the risk of gastric cancer, Mo (OR = 0.52), Ca (OR = 0.16) reduction in stomach cancer onset risk. Conclusion: Plasma levels of certain chemical elements in gastric cancer patients have significant changes compared with the normal population.

結果 (英文) 3:

Objective: to analyze the difference of some chemical elements in the plasma of gastric cancer patients and healthy people and their relationship with gastric cancer. Methods: a total of 10 cases of newly diagnosed cases of gastric cancer were collected in Xianyou County, 299 years or more, and 295 cases were diagnosed by pathology. Get the case and control group by questionnaire and blood samples were collected and the general condition, living habits and other information, using microwave digestion method to detect blood plasma chemical elements by inductively coupled plasma mass spectrometry. The differences of chemical elements in plasma of two groups were compared by non parametric test. Results: the difference of plasma chemical elements in the case group and control group, group Cu, Mg, Cu/Zn higher than the control group (P<0.01), Mo, Ca in case group than in the control group (P<0.01); through the multi factor analysis showed that plasma Cu (OR=2.64), Mg (OR=2.20), Cu/Zn (OR= 3.89) increase the risk of gastric cancer, Mo (OR=0.52), Ca (OR=0.16) to reduce the risk of gastric cancer. Conclusion: the level of some chemical elements in the plasma of patients with gastric cancer has a significant change compared with the normal group.