The DH and PdI of all the LNC-OL batches were determined using dynamic lightscattering (NanoZS, Malvern Instruments, UK). Each sample was diluted in ultrapurewater (1:40) before measurements with the detection angle at 173° and a laserwavelength of 633 nm. LNC zeta potential was measured with the same equipment onthe same sample, with the detection angle at 13° and a 633 nm red laser. Allmeasurements were done in triplicate at 25°C.