The dietary cation-anion difference (DCAD) of diets and acid-base status of cows weremanipulated by incorporating an acidogenic product orby adding salts containing Cl, Na, and K to the diets.Treatments were a base diet (T1; 1.42% K, 0.04% Na,0.26% Cl; DCAD = 196 mEq/kg); the base diet withadded 1% NaCl and 1% KCl (T2; 1.83% K, 0.42% Na,1.23% Cl; DCAD = 194 mEq/kg); the base diet withadded 7.5% acidogenic product, 1.5% NaHCO3, and 1%K2CO3 (T3; 1.71% K, 0.54% Na, 0.89% Cl; DCAD =192 mEq/kg); the base diet with added 7.5% acidogenicproduct (T4; 1.29% K, 0.13% Na, 0.91% Cl; DCAD =−114 mEq/kg); and the base diet with 7.5% acidogenicproduct, 1% NaCl, and 1% KCl (T5; 1.78% K, 0.53%Na, 2.03% Cl; DCAD = −113 mEq/kg). Periods lasted14 d with the last 7 d used for data collection.