Importantly, such heterogeneity was taken into account in our estimation of the association between sedentary time and health outcomes through calculating the Bayesian predictive effect and interval [15]. However, there are some important limitations to consider, one of which is the high reliance on self-reported data. Self- reported sedentary time, in concordance with self-reported behaviour in general, is likely to have poor validity, which would act to weaken the association with health outcomes [49].