ABSTRACT: This study compared the academic and learning characteristics of students with (a)Attention Deficit/Hyperactivity Disorder (AD/HD), (b) giftedness, and (c) giftedness withAD/HD, and examines specific a priori questions. The information reported by teachers, parents, and children was analyzed with a multiple-case design with constant comparative procedures within and across groups. The results indicated that giftedness conferred benefits relatedto specific talents but did not offer protection from the negative outcomes of AD/HD, such asinattention and homework problems. The learning and motivational profiles of each groupwere discussed in terms of implications for differential diagnosis and research and for teachingchildren with AD/HD and giftedness in general and special settings.