The choice of the appropriate model

The choice of the appropriate model and parameter set in determining the relation
between the incidence of radiation pneumonitis and dose distribution in the lung
is of great importance, especially in the case of breast radiotherapy where the
observed incidence is fairly low. From our previous study based on 150 breast
cancer patients, where the fits of dose-volume models to clinical data were
estimated (Tsougos et al 2005 Evaluation of dose-response models and parameters
predicting radiation induced pneumonitis using clinical data from breast cancer
radiotherapy Phys. Med. Biol. 50 3535-54), one could get the impression that the
relative seriality is significantly better than the LKB NTCP model. However, the
estimation of the different NTCP models was based on their goodness-of-fit on
clinical data, using various sets of published parameters from other groups, and
this fact may provisionally justify the results. Hence, we sought to investigate
further the LKB model, by applying different published parameter sets for the
very same group of patients, in order to be able to compare the results. It was
shown that, depending on the parameter set applied, the LKB model is able to
predict the incidence of radiation pneumonitis with acceptable accuracy,
especially when implemented on a sub-group of patients (120) receiving [see
text]|EUD higher than 8 Gy. In conclusion, the goodness-of-fit of a certain
radiobiological model on a given clinical case is closely related to the
selection of the proper scoring criteria and parameter set as well as to the
compatibility of the clinical case from which the data were derived.

結果 (中文) 1:

选择适当的模型和参数设置在确定关系辐射性肺炎和剂量分布的肺癌发病率之间具有重要的意义，尤其是乳腺癌放疗在哪里观察到的发生率是相当低的。从我们前面的研究，基于 150 乳腺癌癌症患者，剂量体积模型对临床数据适合在哪儿估计 （Tsougos et al 2005 评价剂量-反应模型及参数预测辐射诱导肺炎使用从乳腺癌的临床数据放射物理医学 〉 50 3535-54)，你可能得到的印象，相对的转世是明显优于 LKB NTCP 模型。然而，不同的 NTCP 模型的估计基于对其拟合使用发布的参数从其他组，各组的临床数据和这一事实可能暂时说明结果。因此，我们试图探讨进一步的 LKB 模型，通过应用不同的发布的参数设置非常同一组病人，才能够比较的结果。它是结果表明，根据应用的参数集，LKB 模型是能够与可接受的精度，预测放射性肺炎的发生率尤其是当实施小组的病人 (120) 接收 [见上文本] |日币，高于 8 Gy 欧元。在结论中，某些拟合放射生物学模型，在给定的临床病例密切相关选择适当的评分标准和参数设置以及作为为兼容性数据被派生的临床病例。