Recently, we showed that the reduction in DMI in prepartum cows fed diets with acidogenic products was observed regardless of the product fed, either an acidogenic salt or a commercial product (Santos et al., 2018), suggesting that metabolic acidosis and not palatability might be the reason for the reduced intake. We hypothesized that depression in DMI induced by feeding diets with negative DCAD is mediated by changes in acid-base status and not because of inclusion of acidogenic product or salts containing Cl. Thus, the objective was to determine if the decrease in DMI in cows fed acidogenic diets is mediated by the addition of acidogenic product, inclusion of salts containing Cl, or induced by changes in acid-base balance.