Alterations of trace element concen

Alterations of trace element concentrations adversely affect biological processes and could promote carcinogenesis. Only a few studies have investigated the degree of changes in copper and zinc levels in colorectal cancer (CRC). The aim of the present study was to compare the serum copper (Cu) and zinc (Zn) concentrations in patients with CRC from Iran with those of healthy subjects. Cu and Zn concentrations in the serum of 119 cancer patients and 128 healthy individuals were measured by atomic absorption spectrometry. We found a significant decrease in the total mean serum Cu and Zn concentrations in CRC patients as compared with the control group (137.5 ± 122.38 vs. 160.68 ± 45.12 μg/dl and 81.04 ± 52.05 vs. 141.64 ± 51.75, respectively). However, the serum Cu/Zn ratio in the patient group was significantly higher than that measured in the control group (p = 0.00). There was no significant difference in the mean values of serum Cu and Zn concentrations between young (

結果 (中文) 1:

痕量元素浓度的变化产生不利影响的生物过程和能促进癌变。只有几个研究调查在结直肠癌 (CRC) 中的铜、 锌水平变化的程度。本研究的目的是比较血清铜 （铜） 和锌 （锌） 浓度与来自伊朗的 CRC 患者与健康受试者。原子吸收光谱法测定铜和锌浓度血清中 119 癌症患者和健康的 128 人。我们发现显著降低总的平均血清铜和锌浓度 CRC 患者与对照组相比 (137.5 ± 122.38 与 160.68 ± 45.12 μ g/dl 和 81.04 ± 52.05 与 141.64 ± 总额为 5 175，分别)。然而，患者组血清铜/锌比值是明显高于对照组测量 (p = 0.00)。有无显著性在平均值的血清铜和锌浓度之间年轻 (< 60 年) 和老年 （≥ 60 岁）。然而，铜/锌比值在 < 60 年例是明显高于 ≥ 60 岁年龄组 (p < 0.05)。此外，意味着血清铜水平正常体重患者明显高于超重/肥胖例 (132.31 ± 87.43 与 103.81 ± 53.72 μ g/dl，分别) (p < 0.05)。没有任何差别平均血清中的铜和锌浓度由站点、 阶段或分化的肿瘤分级分层的患者。我们的研究结果表明这种不平衡中铜、 锌微量元素水平与 CRC 关联和可能在伊朗患者癌症发展发挥重要的作用。

結果 (中文) 2:

Alterations of trace element concentrations adversely affect biological processes and could promote carcinogenesis. Only a few studies have investigated the degree of changes in copper and zinc levels in colorectal cancer (CRC). The aim of the present study was to compare the serum copper (Cu) and zinc (Zn) concentrations in patients with CRC from Iran with those of healthy subjects. Cu and Zn concentrations in the serum of 119 cancer patients and 128 healthy individuals were measured by atomic absorption spectrometry. We found a significant decrease in the total mean serum Cu and Zn concentrations in CRC patients as compared with the control group (137.5 ± 122.38 vs. 160.68 ± 45.12 μg/dl and 81.04 ± 52.05 vs. 141.64 ± 51.75, respectively). However, the serum Cu/Zn ratio in the patient group was significantly higher than that measured in the control group (p = 0.00). There was no significant difference in the mean values of serum Cu and Zn concentrations between young (<60 years) and elderly (≥60 years) patients. However, the Cu/Zn ratio in <60-year cases was significantly higher than that in ≥60-year age group (p < 0.05). In addition, mean serum Cu level in normal weight patients was significantly higher than that in overweight/obese cases (132.31 ± 87.43 vs. 103.81 ± 53.72 μg/dl, respectively) (p < 0.05). There was no difference in mean serum Cu and Zn concentrations in patients stratified by the site, stage, or differentiation grade of tumors. Our findings suggest that imbalance in Cu and Zn trace element level is associated with CRC and might play an important role in cancer development among Iranian patients.

結果 (中文) 3:

微量元素浓度的改变产生不利影响的生物过程，并可以促进癌变。只有少数的研究调查了在大肠癌（结直肠癌）铜和锌的水平的变化程度。本研究的目的是比较血清铜（铜）和锌（锌）浓度与健康受试者从伊朗与健康受试者的患者。用原子吸收光谱法测定了119例癌症患者和128例健康人血清中的铜和锌的含量。我们发现大肠癌患者的总平均血清Cu和Zn浓度显着下降，与对照组相比（137.5分122.38比51.75，45.12微克/分升和81.04分52.05比141.64，分别为160.68）。然而，在患者组的血清铜/锌比值显着高于对照组（P = 0）。在年轻的血清铜和锌的浓度平均值无明显差异（＜60岁）和老年人（60岁≥）患者。然而，在< 60年情况下，铜/锌比值明显高于≥60岁年龄组（P＜0.05）。此外，正常体重患者的平均血清Cu水平明显高于超重/肥胖者（132.31例87.43和103.81，分别为53.72和D1）（P＜0.05）。平均血清Cu和锌浓度在患者分层的网站，阶段，或分化程度的肿瘤的差异无显著性。我们的研究结果表明，在Cu和锌微量元素水平的不平衡与结肠癌，并可能在伊朗患者的癌症发展中发挥了重要作用。