我們初步發現在急性骨髓性白血病（acute myeloid leuke

我們初步發現在急性骨髓性白血病（acute myeloid leukemia, AML）和急性淋巴細胞性白血病(acute lymphocytic leukemia, ALL)個案中的STR復發、存活率、GVHD grade1-2及CMV在CTLA4基因及TNFSF4基因有顯著的統計相關性。 CTLA-4是免疫球蛋白家族的成員，主要是免疫反應中重要的信號，並且是T細胞活化的負調節劑，而TNFSF4基因為腫瘤壞死因子超家族蛋白的成員是先天或適應性免疫細胞互相協調的關鍵，這些蛋白扮演了免疫細胞生命週期的重要角色，例如區分、啟動、抑制、甚至凋亡，因此對於幹細胞移植之個案都是非常重要的基因。本研究也將持續擴大個案數，提高可信度，利用細胞偵測是否影響生物功能性。最後將利用結果設計SNAPshot assay，對於未來在臨床上移植個案在選擇多位捐贈者時使用，降低移植異常反應。

結果 (英文) 1:

We initially found in acute myeloid leukemia (acute myeloid leukemia, AML) and acute lymphocytic leukemia (acute lymphocytic leukemia, ALL) STR cases of recurrence, survival, GVHD grade1-2 in the CTLA4 gene and CMV gene and TNFSF4 statistical correlation phenomenal. CTLA-4 is a member of the immunoglobulin family, immune responses primarily important signal, and is a negative regulator of T cell activation agent, and TNFSF4 tumor necrosis factor gene is a member of the superfamily proteins innate or adaptive immune cells to each other key coordinate these proteins play an important role in the life cycle of immune cells, for example, to distinguish, to start, suppression, or even apoptosis, and therefore the case for dry cell transplantation is very important gene. The study also will continue to expand the number of cases, improve reliability, the use of cells to detect whether the impact of biological functionality. Finally, using the results of the design SNAPshot assay, for the future in the choice of a number of donors in clinical transplantation cases used to reduce abnormal reaction transplantation.

結果 (英文) 2:

We initially found STR recurrence, survival, GVHD in acute myeloid leukemia (AML) and acute lymphocytic leukemia (acute lymp hocytic leukemia, ALL) There were significant statistical correlations between grade 1-2 and CMV in CTLA4 and TNFSF4 genes. CTLA-4 is a member of the immunoglobulin family, primarily an important signal in the immune response, and is a negative regulator for T-cell activation, while members of TNFSF4 are key to the coordination of innate or adaptive immune cells, which play an important role in the immune cell life cycle. For example, distinguishing, initiating, inhibiting, and even apoptosis, so it is a very important gene for stem cell transplant cases. This study will also continue to expand the number of cases, improve credibility, and use cell detection to detect whether it affects biological function. Finally, the results will be designed using SNAPshot assay to reduce the abnormal response of transplantation when selecting multiple donors for future clinical transplant cases.

結果 (英文) 3:

We initially found that there were significant statistical correlation between STR recurrence, survival rate, GVHD grade1-2 and CMV in CTLA4 gene and TNFSF4 gene in acute myeloid leukemia (AML) and acute lymphocytic leukemia (all) cases. CTLA-4 is a member of immunoglobulin family, mainly an important signal in immune response, and a negative regulator of T cell activation. TNFSF4 is the key to the coordination of innate or adaptive immune cells because the members of tumor necrosis factor superfamily proteins play an important role in the life cycle of immune cells, such as differentiation, activation, inhibition, and even apoptosis. Therefore, it is a very important gene for stem cell transplantation. This study will also continue to expand the number of cases, improve the credibility, and use cells to detect whether the biological function is affected. Finally, we will use the results to design snapshot Asay, which can be used in clinical transplantation cases in the future when multiple donors are selected to reduce the abnormal response of transplantation.