The previous study shown that Physical activity was to improve cognitive through cellular and molecular mechanisms, and change specific areas or behaviors of the brain, and even affect cognitive functions (Stillman, Cohen, Lehman, & Erickson, 2016). ACSM's guidelines indicate 30 min or more of moderate physical activity can Improve cognitive function(Medicine et al., 2018). Hamer and Stamatakis (2009) Physical activity can lead to better cerebral blood flow and Increase cognitive function-related brain regions. It can promote Alzheimer’s disease by increasing neurotrophic factors such as BDNF (Brain- Derived Neurotrophic Factor) and found to enhance brain volume(Erickson et al., 2007). However, neuroprotection may occur through this mechanism, thereby delaying cognitive decline. Since its positive effects, fewer side effects, and low economic burden, it is considered an alternative treatment.