One of the more startling findings

One of the more startling findings of structural
genomics is that structures can often be functionally
interpreted even when their folds are novel. For example,
the discovery of a long, positively charged groove on the
surface of the mouse tubby protein allowed Boggon and
colleagues to postulate that it is a DNA-binding
protein88. The structure also showed that all but one of
the tubby mutations responsible for retinitis pigmentosa type 14 are found in a small region of the groove, even
though they are dispersed within the sequence. Some of
these replace positive amino acids with neutral ones,
strengthening the hypothesis that surface charge is
important. So, not only did three-dimensional structure
provide insight into the molecular function of tubby, but
also it helped to explain disease-causing mutations.

結果 (中文) 1:

更令人吃惊的发现的结构之一基因组学是结构往往可以功能甚至当他们的褶皱是一种新颖的解释。例如，长，带正电槽上的发现鼠标短粗蛋白质表面允许 Boggon 和假设它是 DNA 结合的同事protein88。结构还表明，所有但之一在小区域的槽，甚至发现短粗的突变负责视网膜色素变性类型 14虽然他们分散在序列。一些的这些积极的氨基酸替换中性的加强表面电荷是假设重要的是。所以，不只是三维结构洞察的分子功能的短粗，但它也有助于解释疾病引起的突变。

結果 (中文) 3:

其中一个更惊人的发现结构基因组学的结构往往是功能即使他们的褶皱是新颖的。例如,发现一个长的带正电荷的凹槽老鼠的蛋白质类允许博冈面同事推测这是DNA结合protein88。该结构还显示，只有一个负责视网膜色素变性14型短粗的突变在槽的一个小区域，甚至虽然它们分散在序列内。一些这些取代阳性氨基酸与中性的，加强表面电荷假说重要。所以，不仅三维结构洞察桶状的分子功能，但也有助于解释致病突变。