313. Int J Radiat Oncol Biol Phys.

313. Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):58-67.

The time course of radiation therapy-induced reductions in regional perfusion: a
prospective study with >5 years of follow-up.

Woel RT(1), Munley MT, Hollis D, Fan M, Bentel G, Anscher MS, Shafman T, Coleman
RE, Jaszczak RJ, Marks LB.

Author information:
(1)Department of Radiation Oncology, Duke University Medical Center, Durham, NC
27710, USA.

PURPOSE: To assess the time-dependence of radiation therapy (RT)-induced
reductions in regional lung perfusion, as measured by single photon emission
computed tomography (SPECT) lung perfusion scans.
METHODS AND MATERIALS: Between 1991 and 1999, 79 patients had SPECT lung
perfusion scans before and serially after RT. Changes in regional perfusion were
correlated with regional dose using 3D planning tools and image fusion
(PLUNC-Plan UNC). Multiple post-RT follow-up scans were evaluated to determine
the temporal nature of RT-induced regional perfusion changes. To facilitate the
comparison of dose-response curves (DRCs) at different post-RT intervals, each
DRC was fit to a linear model and thus described by its slope.
RESULTS: There was a dose-dependent reduction in regional perfusion at nearly all
time points post-RT (p = 0.0001). The slope of the DRCs for RT-induced reductions
in regional perfusion became steeper at essentially each successive follow-up
interval (p = 0.0001). However, the increases in slope became progressively
smaller at later follow-up intervals. Overall, about 80% of the long-term
RT-induced regional perfusion injury was manifest within 12 months post-RT.
CONCLUSION: There is a progression of RT-induced reductions in regional
perfusion, with most of this injury manifest within 12 months post-RT. Additional
regional injury appears to evolve for years.

PMID: 11777622 [PubMed - indexed for MEDLINE]

結果 (中文) 1:

313.Int J 辐射 Oncol 生物学与物理 2002 年 1 月 1 日; 1:58-67。辐射诱导治疗减少区域灌注的时间进程︰前瞻性研究 > 5 年的随访。Woel RT(1)，蕾 MT，霍利斯 D、 风扇 M、 Bentel G、 Anscher 女士，Shafman T 科尔曼稀土、 Jaszczak RJ，标志着磅。作者信息︰(1)辐射部肿瘤，杜克大学医学中心，达勒姆，数控27710，美国。目的︰ 评估放射治疗 (RT) 随时间变化的诱导减少区域肺灌注，按单光子发射计算机断层扫描 (SPECT) 肺灌注扫描。方法和材料︰ 1991 年至 1999 年，79 患者 SPECT 肺灌注扫描之前和串行，室温变化在区域灌注后与使用三维规划工具和图像融合的区域剂量相关(PLUNC 计划 UNC)。多个职位-RT 后续扫描被评估以确定RT 诱导的区域灌注变化的世俗性质。以方便剂量-反应曲线 (DRCs) 按不同的员额 RT 的时间间隔，比较每个刚果 （金） 是适应线性模型，因而由其坡面描述。结果︰ 有是在几乎所有区域灌注剂量依赖性地减少时间点后 RT (p = 0.0001)。边坡的 RT 诱导削减危难在区域灌注变陡峭在本质上是每个连续的后续行动间隔 (p = 0.0001)。然而，在边坡中的增加逐步成为了在以后的随访时间间隔较小。总体而言，约 80%的长期RT 诱导的区域灌注损伤是在 12 个月后室温内清单结论︰ 有什么 RT 诱导减少区域的进展灌注，大部分内 12 个月后室温附加此损伤清单区域损伤出现演变为年。PMID: 11777622 [PubMed-索引为 MEDLINE]

結果 (中文) 3:

313。j的放射肿瘤学的生物物理。1月1日2002；52（1）：58-67。放射治疗引起的局部灌注减少的时间过程随访5年的前瞻性研究。woel RT（1），Munley MT，Hollis D，范，Bentel G，安舍小姐，Shafman，科尔曼再次，Jaszczak RJ，Marks LB.作者信息：（1）放疗科，北卡罗莱纳州达勒姆的杜克大学医学中心，NC27710、USA.前言：目的：评价放射治疗（放疗）诱导的时间依赖性单光子发射测量的区域肺灌注的减少计算机断层扫描（SPECT）肺灌注扫描。材料与方法：1991和1999之间，79例SPECT肺灌注扫描前和连续后局部灌注，变化使用三维规划工具和图像融合相关的区域剂量（PLUNC计划UNC）。多个后续的后续扫描进行评估，以确定局部大区域血流灌注变化的时间特性。为了方便剂量-反应曲线的比较（DRC）在放疗后间隔不同，每DRC是适合的线性模型，其坡度这样描述。结果：几乎所有的区域灌注有剂量依赖性的减少时间点后（P = 0.0001）。RT诱导减少边坡的DRC在区域灌注变得更陡在本质上是每一个连续的后续间隔（P = 0.0001）。然而，坡度的增加逐渐在后续的时间间隔较小。总体而言，约有80%的长期RT诱发区域灌注损伤明显放疗后12个月内结论：有一个进展的大局部在区域内引起的减少灌注，12个月内增加放疗后这种损伤的表现最区域损伤出现多年的发展。发表于：11777622 [ PubMed索引数据库]