What is an unculturable bacterium?

W
hat is an unculturable bacterium? While at first glance, there
appears to be a contradiction in the title of this review, in this
context, “unculturable” indicates that current laboratory culturing
techniques are unable to grow a given bacterium in the laboratory.
That all organisms must be growing in their natural environment is
axiomatic;thatmanywecannotcurrentlygrowwillbeculturedinthe
futureiscertain.Therefore,“unculturable”doesnotmean“cannever
becultured”but,rather,signifiesthatwelackcriticalinformationon
their biology, and this presents both challenges and opportunities.
Theseopportunitiesarethechancetolearnthemolecularprinciples
behind this recalcitrant growth, allowing us to add that information
toourrepertoireofmicrobiologicaltechniquesandgainingaccessto
previously hidden metabolic diversity that will provide new natural
products and reveal factors that can contribute to both ecological
balanceandhosthealth.Thisreviewexaminestherecentapproaches
thatmicrobiologistsareemployingtoconvertcurrentlyunculturable
bacteria into cultured isolates in the laboratory while concurrently
beginningtodiscoverthemechanismsbehindtheirapparentuncul-

結果 (中文) 1:

W
帽子是不可培养的细菌？而乍一看，有似乎是一对矛盾在这篇评论的标题，在这个
上下文，“不可培养”表示，目前实验室培养
技术是无法在实验室里长出了细菌。
所有生物必须可在自然环境中成长
不言自明; thatmanywecannotcurrentlygrowwillbeculturedinthe
生物学，这带来的挑战和机遇并存。
theseopportunitiesarethechancetolearnthemolecularprinciples，
背后这个顽抗增长，使我们能够将该信息添加
toourrepertoireofmicrobiologicaltechniquesandgainingaccessto
以前隐藏的代谢多样性，自然
将提供新的产品和揭示，可以促进双方的因素到在实验室中培养的菌株，同时兼
beginningtodiscoverthemechanismsbehindtheirapparentuncul的

結果 (中文) 2:

W是一个不可培养细菌
帽子？虽然乍一看，有
似乎在这篇评论的标题的矛盾，在这
语境，“不可培养”表明，目前实验室培养
技术是无法生长在实验室的一个给定的细菌。
所有生物必须在自然环境中生长的thatmanywecannotcurrentlygrowwillbeculturedinthe

公理；"Futureiscertain.Therefore, unculturable" doesnotmean "cannever
becultured" but, rather, signifiesthatwelackcriticalinformationon
their biology, and this presents both challenges and opportunities.
Theseopportunitiesarethechancetolearnthemolecularprinciples
behind this recalcitrant growth, allowing us to add that information
toourrepertoireofmicrobiologicaltechniquesandgainingaccessto
以前隐藏的代谢多样性，将提供新的自然
产品和显示，可以促进生态
balanceandhosthealth因素。thisreviewexaminestherecentapproaches
thatmicrobiologistsareemployingtoconvertcurrentlyunculturable
细菌培养分离株在实验室同时
beginningtodiscoverthemechanismsbehindtheirapparentuncul—

結果 (中文) 3:

W
帽子是无法细菌吗？看第一眼，那里段时间
似乎是一个矛盾的标题中的检讨，这
背景下，"无法"指示当前实验室培养
技术就不能生长一给定的细菌在实验室中进行。
必须在其自然的环境中增长所有有机体是
公理 ； thatmanywecannotcurrentlygrowwillbeculturedinthe
futureiscertain。因此，"无法"doesnotmean"cannever
becultured"，但，相反，signifiesthatwelackcriticalinformationon
他们的生物，而这带来的挑战和机会。
Theseopportunitiesarethechancetolearnthemolecularprinciples
后面这个顽固的增长，使我们能够将这些信息添加
toourrepertoireofmicrobiologicaltechniquesandgainingaccessto
以前隐藏的代谢的多样性，它将提供新自然
产品和揭示因素可以导致两个生态
balanceandhosthealth。Thisreviewexaminestherecentapproaches
thatmicrobiologistsareemployingtoconvertcurrentlyunculturable
细菌培养分离株在实验室里虽然同时入
beginningtodiscoverthemechanismsbehindtheirapparentuncul-