Linalool oxide is a monoterpene that is found in some species of aromatic plants. In the present study, the effect of linalool oxide was investigated in mice, being administered by inhalation at concentrations of 0.65%, 1.25%, 2.5% and 5.0%. Results show that the anxiolytic drug profile of this monoterpene is similar to that of linalool in mice when a 3% concentration is inhaled (Linck et al., 2010).In this study, linalool oxide increased the number of entries into the open arms of the device (Fig. 1) and the time spent in the open arms of the maze (Fig. 2), behaviors indicative of anxiolytic activity and similar to the positive pattern effects expected following the use of diazepam.The total distance traveled by the animals is a measure of locomotor activity (Faturi et al., 2010), and the results showed that linalool oxide increased ambulation in these animals (Fig. 3).