Crystallography has benefited from many technologies,
including the brilliance of synchrotron radiation
and its tunability for multiple anomalous dispersion
(MAD) PHASING36.Other improvements include
charged coupled device detectors, as well as the
enhanced stability provided by cryocrystallography.
NMR has seen similar advances, including cryogenic
probes and higher-field magnets, as well as new techniques
such as transverse relaxation-optimized spectroscopy
(TROSY)32,37. Consequently, although early
plans for structural genomics focused primarily on
crystallography, NMR has already proved to have
great value for the field32,38.At this time, most centres
in the United States have NMR spectroscopists, and roughly half of the structural genomics effort in Japan
use NMR39,30.