SRA, which has function analogous to Evf2, is a coactivator fornuclear receptors (NRs). SRA fulfills its activation function throughthe AF-1 domain of the nuclear receptors [11]. The level of SRA isincreased in breast tumors and may alter ER/PR action and pro-mote tumorigenesis [45]. Recent studies have revealed that theSRA1 gene modulates the activity of steroid receptors at both theRNA (SRA) and protein (SRAP) levels [82,83]. The balance of non-coding and coding SRA transcripts is important because it not onlycharacterizes some particular tumor phenotypes, but might also beinvolved in breast tumorigenesis and tumor progression throughthe regulation of specific genes expression [82]