There is little
support for this view however, since ak mice showed no evidence of
global neurological deficits or severe motor disturbance in any of the
paradigms tested here, which is consistent with our previous studies.
ak mice did not differ from wt or rd1 mice on day 1 baseline
performance of any of the tasks tested. Instead the main difference
observed between ak mice and the wt and rd1 mice is that ak mice
failed to demonstrate experience-dependent change in behavior. This
is consistent with the idea of select striatum-dependent learning and
memory impairment in ak mice.