A second limitation was the difficulty in estimating a minimum effective “dose” of hatha yoga to produce mood effects. Yoga completers in this trial achieved a mean adherence rate of 74% to the prescribed dose of 90 minutes of yoga practice twice weekly for 8 weeks, and this intensity of practice may have produced sufficient yoga-specific mood benefit by 8 weeks to differentiate BDI scores in the two groups. However, in prior RCTs of yoga mono-therapy for major depression [70–72], yoga-specific mood benefit appeared to emerge in just 4 weeks— perhaps because yoga sessions were assigned on a daily or near-daily basis and conducted in residential or inpatient settings with nearly 100% participant adherence. If yoga-specific mood benefits of this hatha yoga sequence are confirmed in future RCTs, next steps might be to test whether increased practice intensity and/or increased adherence promote earlier manifestation of mood effects. One method to increase practice frequency (and perhaps enhance adherence) would be to augment on-site group practice with home practice, using instructional DVDs or online sessions. A trial period of 24 weeks would clarify longer-term impact on mood outcomes.