In the aged skin, the number of dermis and epidermis cells may reduce, and the cells become less functional, resulting in wrinkle formation,pigmentation, dryness, thick skin, and decreased elasticity [3].The exposure to UV light induces the production of matrix metalloproteinases (MMPs) in human skin. MMPs are responsible for the degradation of the ECM proteins such as collagen, elastin.and proteoglycans [3,4]. MMPs are divided into about five major subgroups according to their substrate characteristics, structure, and localization.