To further ensure the synthesized data contain distinguishable CS cancerous patterns, we compute the Auxiliary Distances (AD) of Jensen–Shannon divergence (JSD) between the synthetic CS and real nonCS images of the two modalities. By maximizing the two ADs, in addition to minimizing the W-distances in the unsupervised training process, the synthesizer is guided to include meaningful CS PCa features through attempting to better distinguish the synthesized CS mp-MRI data from those real nonCS mp-MRI data.