Moreover, the long-chain derivatives of PUFAs such as arachidonic acid (20:4 n 2 6), eicosapentaenoic acid (20:5 n 2 3) and docosahexaenoic acid (22:6 n 2 3) are identified as potent signaling molecules that regulate the expression of proteins involved in lipid and carbohydrate metabolism and thereby enhance insulin sensitivity (6).