Finally, the Mirror Therapy in Unilateral Neglect After Stroke (MUST) trial tested the efficacy of mirror therapy for hemispatial neglect in 48 patients enrolled within 48 h of stroke. Patients received either mirror therapy or sham immediately prior to standard OT for 1–2 h/day, 5 days/week for 4 weeks. This study was positive, finding significant improvement in the intervention group compared with controls on neglect outcomes: star cancelation, line bisection, and picture identification. The treatment group also had significantlygreater FIM scores at 3 and 6 months post-treatment.In sum, the current evidence does not support the use of hemifield patching in the acute phase of stroke, but mirror therapy may be a promising treatment. The HEP trials highlight the need for biomarkers to better predict the course of neglect in individual patients—given thehigh rate of spontaneous resolution of neglect, in order to prove the benefit of early interventions, we need methods to predict who is likely to recover spontaneously and who is not.