So far, different models for adaptation to chronic illnesshave been suggested. Bio-medical models mainlypay attention to physical adaptation and physiologicalconsequences, while psychological ones put emphasison behavioral reactions and psychic outcomes. In spiteof the positive benefits of these models, they have particularlimitations for clinical application (21). In parallelto bio-psychosocial models; nursing models have alsobeen introduced by nursing scholars who emphasize onthe holistic concept of the human being. Among nursingmodels, Roy’s Adaptation Model (RAM) is one, whichwould form the conceptual framework of the presentstudy. Application of this model has been interesting fornursing researchers in clinical settings (22-25). Adaptationis the main concept of RAM and the goal of nursingis promotion of adaptation in each of the four modesnamely physiological, self-concept, role function andinterdependence. Nursing interventions contribute torestoration and maintenance of the patient’s adaptationthrough changing or manipulating the internal and externalstimuli (26). The nursing care program of ESRD isa complex plan. It not only includes dialysis therapy butalso involves fundamental changes in life style for facilitatingthe patient’s adaptation to chronic renal diseaseand its consequences. Ineffective adaptation reducesquality of life and increases treatment expenses. Numerousstudies have investigated the effects of patient educationon physical or psychological outcomes in ESRD, butonly a few researches investigating the effects of RAMbasedinterventions in HD patients have been conducted.The patients’ frequent attendances to dialysis wardsmake an opportunity to implement nursing modelbasededucation. This would increase patient knowledgeabout self-care behaviors, coping with renal disease andadaptation to the long-term dialysis plan.