RESULTS AND CONCLUSION: The major p

RESULTS AND CONCLUSION: The major pro-inflammatory cytokines in the radiation
response of the lung include tumor necrosis factor-alpha (TNF-alpha),
interleukin-1 (IL-1), and interleukin-6 (IL-6). Transforming growth factor-beta
(TGF-beta) appears to be of particular importance in the development of lung
fibrosis. First approaches with radioprotective agents and gene therapy to modify
radiation-induced cytokine expression have been investigated for prevention of
late effects of irradiation lung damage in animal experiments. Preliminary data
of clinical studies suggest that elevated plasma TGF-beta-levels during
radiotherapy may predict the development of symptomatic radiation pneumonitis.
The biological impacts of endogenous radiation-induced cytokine production by
tumor cells in respect of tumor behavior, potential damage to normal tissue, and
clinical status of the host still need to be determined more precisely.

結果 (中文) 1:

结果与结论︰ 主要炎性细胞因子的辐射肺的响应包括肿瘤坏死因子-α （TNF-α），白细胞介素-1 (IL-1) 和白细胞介素-6 (IL-6)。转化生长因子 β（TGF-β） 似乎在肺癌的发展特别重要纤维化。第一个方法与辐射防护剂和修改的基因疗法辐射诱导的细胞因子的表达有追究的预防辐照肺损伤的动物实验的晚期效应。初步数据临床研究表明，升高血浆 TGF-β-水平期间放射治疗可以预测症状性放射性肺炎的发展。产生内源性辐射诱导的细胞因子对生物的影响肿瘤细胞对肿瘤的行为，对正常组织的潜在损害和主机的临床状态仍需要更精确地确定。

結果 (中文) 3:

结果与结论：辐射中主要的促炎性细胞因子肺的反应包括肿瘤坏死因子α（肿瘤坏死因子α），白细胞介素-1（IL-1）、白细胞介素-6（IL-6）。转化生长因子β（TGF-β）似乎是在肺发育特别重要纤维化。第一个方法与辐射防护剂和基因治疗的修改辐射诱导的细胞因子的表达进行了研究，以预防放射性肺损伤在动物实验中的晚期效应。初步数据临床研究表明，血浆TGF-β水平在放疗可预测放射性肺炎症状的发展。内源性辐射诱导细胞因子产生的生物学效应肿瘤细胞在肿瘤行为方面，对正常组织的潜在损伤，以及主机的临床状态仍然需要更精确地确定。