Experimental structural genomics faces no single
bottleneck to overcome: nearly every stage of the process
needs to be refined and optimized.Moreover,many individual
proteins are expected to be intractable without
specialized extensive effort.Therefore, parallel studies on
related proteins are being relied on to increase the likelihood
of readily solving a structure for a family of proteins.
The progress of individual protein targets through
the experimental process will be like a funnel,with many
targets starting at the same time, and a fraction failing at
each stage of the process. The slope of the funnel is
dependent on the effort devoted at each step,which is, in
turn, a consequence of the specific motivations of the
particular structural genomics centre.