The presence or absence of the different domains in p63
isoforms affects not only their transactivation capacity, but
also their stability. TAp63γ has the greatest transactivation
potential on a p53-responsive promoter [3], as is expected
from its TA domain and lack of a PID. However, TAp63
isoforms have a much shorter half-life than ΔNp63 isoforms
and are quickly degraded when expressed exogenously