Long term in vitro biostability of

Long term in vitro biostability of segmented polyisobutylene-based thermoplastic polyurethanes†.
Long term in vitro biostability of thermoplastic polyurethanes (TPUs) containing mixed polyisobutylene (PIB)/poly(tetramethylene oxide) (PTMO) soft segment was studied under accelerated conditions in 20% H2O2 solution containing 0.1M CoCl2 at 50°C to predict resistance to metal ion oxidative degradation (MIO) in vivo. The PIB-based TPUs showed significant oxidative stability as compared to the commercial controls Pellethane™ 2363-55D and 2363-80A. After 12 weeks in vitro the PIB-PTMO TPUs with 10–20% PTMO in the soft segment showed 6–10% weight loss whereas the Pellethane™ TPUs degraded completely in about 9 weeks. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the degradation of Pellethane™ samples via MIO by the loss of the ∼1110 cm−1 aliphatic C O C stretching peak height attributed to chain scission, and the appearance of a new peak at ∼1174 cm−1 attributed to crosslinking. No such changes were apparent in the spectra of the PIB-based TPUs. The PIB-based TPUs exhibited 10–30% drop in tensile strength compared to 100% for the Pellethane™ TPUs after 12 weeks. The molecular weight of the PIB-based TPUs decreased slightly (10–15%) at 12 weeks. The Pellethane™ TPUs showed a dramatic decrease in Mn and an increase in low molecular weight degradation product. Scanning electron microscopy (SEM) showed severe cracking in the Pellethane™ samples after 2 weeks, whereas the PIB-based TPUs exhibited a continuous surface morphology. The weight loss, tensile, and SEM data correlate well with each other and indicate excellent biostability of these materials.

結果 (中文) 1:

长期分段聚异丁烯基热塑性 polyurethanes† 体外的生物。长期体外生物的热塑性聚氨酯 (Tpu) 包含混合聚异丁烯 (PIB) / poly(tetramethylene oxide) (拉伸) 软段研究了下加速在含 0.1 M CoCl2 在 50 ° C，预测金属离子氧化降解 (MIO) 在体内抗 20 %h2o2 溶液中的条件。表现出显著的氧化稳定性，而商业控件 Pellethane ™ 的基于 PIB 的 Tpu 2363 55 D 和 2363年 80A。后 12 周体外 PIB 拉伸 Tpu 与软段在 10 — — 20%拉伸显示 6 — — 10%的重量损失，而 Pellethane ™ Tpu 已完全降解约 9 周。衰减全反射傅里叶变换红外光谱证实 Pellethane ™ 样品通过宇达电通的脂肪族 C O C 拉伸峰值高度归因于断链，∼1110 cm − 1 的损失和外观的一个新的高峰，在 ∼1174 cm − 1 归因于交联退化。没有这种变化，明显在基于 PIB 的 Tpu 的光谱。基于 PIB 的 Tpu 展出拉伸强度相比 Pellethane ™ Tpu 100 %12 周后下降 10-30%。分子量为基于 PIB 的 Tpu 略有下降 (10-15%) 在 12 个星期。Pellethane ™ Tpu 表明锰急剧减少和增加，在低分子量降解产物。扫描电子显微镜 (SEM) 显示严重开裂 Pellethane ™ 样品中 2 周后进行的而基于 PIB 的 Tpu 展出连续的表面形貌。减肥，拉伸，扫描电镜和数据不与对方密切相关表明优秀生物的这些材料。

結果 (中文) 3:

在分段的聚异丁烯的体外稳定性长期型热塑性聚氨酯†。
在热塑性聚氨酯（TPU）的体外稳定性长期含聚异丁烯（PIB）/聚（四氢呋喃）（PTMO）软段进行了加速条件下H2O2溶液含有0 20%。1M氯化钴50°C预测抗金属离子氧化降解（MIO）体内。PIB基于TPU呈现明显的氧化稳定性比商业控制™2363-55d PELLETHANE 2363-80A和。12周后在体外pib-ptmo TPU 10–20% PTMO软段中显示6–10%减肥而PELLETHANE™TPUs完全降解约9周。衰减全反射傅里叶变换红外光谱证实™PELLETHANE样本降解通过我的∼1110厘米−1脂肪族C O C伸缩峰归因于断链的损失，并在∼1174厘米−1归因于交联新高峰的出现。没有这样的变化明显的PIB的光谱为基础的TPU。PIB基于热塑性聚氨酯表现出10–下降30%，抗拉强度比100%个12周后的™PELLETHANE。分子量的聚异丁烯基TPU略有下降（10–15%）12周。™TPUs的PELLETHANE表明Mn的急剧下降和低分子量的降解产物的增加。扫描电子显微镜（SEM）显示严重开裂的PELLETHANE™样品后的2个星期，而PIB基于热塑性聚氨酯表现出连续的表面形貌。拉伸的重量损失，和SEM数据以及彼此相关，表明这些材料具有优异的生物稳定性。