A major contributor to high-cost medical care is unplanned medical admissions and postadmission events. Improving a patient’s functional status, reducing symptom burden, building strength reserves and observing patients in a medical environment during the transition from acute care to discharge home could potentially reduce hospital readmission from the community. This also could result in better medical outcomes and reduced cost. Does the higher therapy intensity and greater physician involvement in an IRF compared to a SNF reduce the risk of hospital readmission of cancer patients? Due to the natural history of oncological disease, particularly in advanced cases, as well as the side-effects of treatment and associated co-morbid conditions, many cancer patients are at risk for unanticipated hospital readmissions. There are no published studies on the possible impact of different inpatient rehabilitation settings on the readmission rate of cancer patients. Research is needed.