Our aim in the present study is to increase grease separation by optimising the discharge performance ofcooking oil fumes. A novel range hood with an outer cylinder and guide vanes of exhaust (GVE) is proposed.The geometric configuration of the hood is optimized by a reverse design method developed bycoupling back propagation neural networks, mind evolutionary algorithms, and computational fluidmechanics. The primary objective of the range hood is to maximise the exhaust airflow rate with goodgrease separation. At the optimised conditions, the inlet and outlet blade angles are 80 and 176, respectively,while the heights of the blade and guide vane are 0.180 and 0.245 m, respectively. The optimalnumber of blades and guide vanes are 29 and 7, respectively, while the optimal diffuser diameter is0.340 m. The proposed range hood exhibits excellent performance of grease particle separation comparedto multi-blade centrifugal fans with volutes. In addition, the outer cylinder and GVE of the range hoodexhibit a large separation efficiency for particles in the size range of 1–4 lm, while impeller bladesmainly separate grease particles in the size range of 4–10 lm.