多環芳香烴 BP 是香煙中的一種致癌物。多環芳香烴被代謝成 BPDE

多環芳香烴 BP 是香煙中的一種致癌物。多環芳香烴被代謝成 BPDE 後會在 DNA 的 CpG 序列上產生大型鍵結物。如果這種 DNA 損傷發生在抑癌基因 p53 的 DNA 序列上而沒有修復，將造 成 p53 序列改變，失去功能，最後可能形成癌症。請問修復 DNA 大型鍵結物的主要機制是?a) Nucleotide excision repairb) Base excision repairc) Mismatch repaird) Homologous recombination

結果 (英文) 1:

Polycyclic aromatic hydrocarbon BP is a carcinogen in cigarettes. When PAHs are metabolized into BPDE, large bonds are produced on the CpG sequences of DNA. If this kind of DNA damage occurs to the DNA sequence of the tumor suppressor gene p53 and is not repaired, it will cause the p53 sequence to change, lose its function, and eventually form cancer. What is the main mechanism for repairing large DNA bonds? a) Nucleotide excision repair b) Base excision repair c) Mismatch repair d) Homologous recombination

結果 (英文) 2:

Polycyclic aromatic hydrocarbon BP is a carcinogen in cigarettes. After being metabolized into BPDE, polycyclic aromatic hydrocarbons produce large bonds on the CpG sequence of DNA. If this DNA damage occurs on the DNA sequence of the tumor suppressor gene p53 without repair, it will cause changes in the p53 sequence, loss of function, and ultimately the formation of cancer. What is the main mechanism for repairing large DNA bonds?
a) Nucleotide exception repair
b) Base exception repair
c) Mismatch repair
d) Homologous recombination

結果 (英文) 3:

Polycyclic aromatic hydrocarbon BP is a carcinogen in cigarettes. Polycyclic aromatic hydrocarbons are metabolized into BPDE, which will produce large bonds on the CpG sequence of DNA. If this DNA damage occurs on the DNA sequence of the tumor suppressor gene p53 without repair, the p53 sequence will change, lose its function, and finally may form cancer. Excuse me, what is the main mechanism of repairing DNA large bonds?
a) Nucleotide excision repair
b) Base excision repair
c) Mismatch repair
d) Homologous recombination