Figure 1 | The writer, eraser and reader proteins of m6
A.
The deposition, removal and recognition of
N6
-methyladenosine (m6
A) are carried out by cognate
factors termed writers, erasers and readers, respectively.
Mammalian m6
A writers function as a protein complex with
four identified components so far: methyltransferase-like 3
(METTL3), METTL14, Wilms tumour 1‑associated protein
(WTAP) and KIAA1429. Two m6
A erasers have been
reported: fat mass and obesity-associated protein (FTO)
and alkB homologue 5 (ALKBH5). The function of m6
A is
mediated partly by reader proteins, which have been
identified in members of the YT521‑B homology (YTH)
domain-containing protein and the heterogeneous nuclear
ribonucleoprotein (HNRNP) protein families.
Figure 1 | The writer, eraser and reader proteins of m6
A.
The deposition, removal and recognition of
N6
-methyladenosine (m6
A) are carried out by cognate
factors termed writers, erasers and readers, respectively.
Mammalian m6
A writers function as a protein complex with
four identified components so far: methyltransferase-like 3
(METTL3), METTL14, Wilms tumour 1‑associated protein
(WTAP) and KIAA1429. Two m6
A erasers have been
reported: fat mass and obesity-associated protein (FTO)
and alkB homologue 5 (ALKBH5). The function of m6
A is
mediated partly by reader proteins, which have been
identified in members of the YT521‑B homology (YTH)
domain-containing protein and the heterogeneous nuclear
ribonucleoprotein (HNRNP) protein families.
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