In general, psychological and social care for patients with epilepsy have been advocated in reference books on epilepsy, and a major part of the comprehensive care for patients with chronic diseases is to increase their knowledge about the disease. The improvement of the health-related quality of life of patients with epilepsy is known as an essential component of epilepsy treatment.Training programs for patients and parents (caregivers) of children with epilepsy are especially important in their comprehensive management.In this respect, this study was conducted to determine the effect of a self-management training program on quality of life in patients with epilepsy.The results of this study showed that the two groups were matched before the intervention in terms of demographics, disease symptoms, and quality of life and its dimensions. After the intervention, quality of life and its dimensions in the case group improved significantly, and the difference between case and control groups was statistically significant.