As per CRASH-2 trial in 2010 for evaluation of the role of tranexamic acid, 20,000
trauma patients were randomized to receive either tranexamic acid or control. Tranexamic acid significantly reduced the risk of death (odds ratio [OR]: 0.91 [0.85-0.97], P = 0.0035) and death from hemorrhage (OR: 0.85 [90.76-0.96], P < 0.001)without any increase in thromboembolic complication.